Country for PR: Japan
Contributor: Kyodo News JBN
Friday, February 26 2021 - 18:00
Kyushu University Confirms HORIUCHI L-FUCOIDAN Inhibits Binding between ACE2 and Virus Spike Protein (Derived from COVID-19)
KURUME, Japan, Feb. 26, 2021 /Kyodo JBN-AsiaNet/ --

FCC Horiuchi Co., Ltd. based in Kurume City, Fukuoka Prefecture, western Japan, 
has conducted an experiment in inhibiting binding between ACE2 and virus spike 
protein using HORIUCHI L-FUCOIDAN, manufactured by the company, in 
collaboration with a graduate school of Kyushu University (Associate Professor 
Kuniyoshi Shimizu of Division of Sustainable Bioresources Science, Department 
of Agro-Environmental Sciences, Faculty of Agriculture).

Angiotensin Converting Enzyme II (ACE2) provides a foothold when COVID-19 and 
SARS viruses enter human cells. If the binding of viral spike protein to ACE2 
can be inhibited, viruses cannot enter human cells, and so the protective 
effect against COVID-19 can be expected.

Figures courtesy of Kyushu University:

Originally, fucoidan is a high-molecular-weight polysaccharide, but HORIUCHI 
L-FUCOIDAN is a low-molecular-weight fucoidan which is composed of 500 or less 
molecular weight by the company's original technique. To evaluate whether 
fucoidan inhibits the binding of ACE2-virus spike protein, a kit containing 
ACE2 and coronavirus spike protein was used. L-FUCOIDAN or H-FUCOIDAN (high 
molecular weight) was incubated together with ACE2 and virus spike protein and 
the binding inhibition activity was measured.

L-FUCOIDAN showed approximately 100% ACE2-virus spike protein binding 
inhibition activity at 1.15 mg/mL (left side of the figure below). On the other 
hand, H-FUCOIDAN (high molecular weight) showed about 20 to 30% of binding 
inhibition activity in all the tested concentrations. It did not show as much 
inhibition activity as L-FUCOIDAN (right side of the figure below).


*Data courtesy of Kyushu University.

This suggests that HORIUCHI L-FUCOIDAN can be expected to have a preventive 
effect against COVID-19.

Source: FCC Horiuchi Co., Ltd.